SUMMARY Local anesthetics LA are drugs widely used in the practice of anesthesia, with low incidence of adverse events; however, in case of toxicity , mortality is very high. Currently, the systemic toxicity rates have dropped from 0. In view of the high risk of latent mortality, studies in humans are not feasible and hence the available sources of information are extrapolated animal studies or case reports. Severe LA toxicity manifestations occur mainly as a result of intravascular administration rather than due to tissue absorption; hence, bupivacaine is the LA that exhibits the highest risk. Clinically there are awareness disorders and tonic-clonic seizures followed by cardiovascular involvement resulting from conduction blocks and difficult to manage cardiovascular collapse.

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Toggle navigation. Der Arzneistoff wird als Racemat eingesetzt. Es hat einen relativ langsamen Wirkungseintritt und eine lange Wirkungsdauer, die bis zu 12 Stunden andauert. It is used by injecting it into the area, around a nerve that supplies the area, or into the spinal canal's epidural space. It is available mixed with a small amount of epinephrine to make it last longer. It typically begins working within 15 minutes and lasts for 2 to 8 hours. Possible side effects include sleepiness, muscle twitching, ringing in the ears, changes in vision, low blood pressure, and an irregular heart rate.


A dose perineal de 20 mg foi realizada em todas as pacientes dos 2 grupos. Aos 15 minutos, no grupo I todas as pacientes apresentavam dor igual ou inferior a 3. No grupo II, neste momento, uma paciente apresentava intensidade 5 e todas as outras apresentavam inferior a 3. Aos 30 minutos somente uma paciente do grupo II apresentava dor de intensidade 4.

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