Justicia secunda Vahl is an exotic plant that is used to treat medical problems. We investigated the hepatoprotective and hematological effects of aqueous extracts of J. Leaf extracts were prepared using hot and cold extraction methods to obtain a hot extract of J. Total phenol and flavonoid measurements and antioxidant assays were performed to determine the extract with the greater antioxidant activity. JSHAE was the more effective extract for treatment of carbon tetrachloride CCl 4 induced hepatotoxicity and hepatotoxicity in rats. Silymarin was used as a standard for comparison.

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Background: Sickle cell disease or drepanocytosis is caused by the polymerisation of abnormal haemoglobin S when oxygen tension decreases. This lead to the changes in the shape of red blood cells and anaemia. It has also been postulated that the red cells of patients with sickle cell disease contain a higher than normal concentration of calcium ions.

These ions are bound to membrane proteins resulting in dehydration and loss of red blood cell deformability and cell-to-cell adherence. Anthocyanins extracted from some Congolese plants used in traditional medicine against sickle cell disease have recently been shown to have anti-sickling activity in vitro. Justicia secunda is a plant used in Congo by Jehovah's Witnesses, well known for their refusal of blood transfusions, against anaemia.

Materials and methods: Emmel, Itano and osmotic fragility tests were used to test the effect of anthocyanin extracts from Justicia secunda leaves on haemoglobin S solubility and sickle cell membrane stability. Results: Anthocyanins from Justicia secunda were found to possess anti-sickling activity.

Treated SS red blood cells recovered a normal, classical biconcave form with a radius of 3. The solubility of deoxyhaemoglobin S increased and the osmotic fragility of drepanocytes decreased upon treatment with anthocyanin extracts. Conclusion: These findings suggest that anthocyanin extracts play a role in both stabilising the red blood cell membrane and inhibiting polymerisation of haemoglobin S.

This provides a possible molecular basis for earlier reports on the anti-sickling properties of anthocyanins from some Congolese plants and their use in the management of sickle cell disease by Congolese traditional healers. Keywords: Justicia secunda; anthocyanin extracts; anti-sickling activity; osmotic fragility; polymerisation. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.

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Save Cancel. Create a file for external citation management software Create file Cancel. Full-text links Cite Favorites. Abstract Background: Sickle cell disease or drepanocytosis is caused by the polymerisation of abnormal haemoglobin S when oxygen tension decreases. Figures Figure 1 5 Morphology of untreated SS red…. Figure 1 13 Morphology of untreated SS red blood cells control X Figure 2 5 Morphology of SS red blood…. Figure 2 13 Morphology of SS red blood cells treated with 0.

Morphology of SS red blood cells treated with 0. See this image and copyright information in PMC. Similar articles Antisickling activity of anthocyanins from Bombax pentadrum, Ficus capensis and Ziziphus mucronata: photodegradation effect. Mpiana PT, et al. J Ethnopharmacol. Epub Sep PMID: Phytomedicines and nutraceuticals: alternative therapeutics for sickle cell anemia.

Imaga NA. Epub Feb The in vitro antisickling and antioxidant effects of aqueous extracts Zanthoxyllum heitzii on sickle cell disorder. Pauline N, et al. In vitro antidrepanocytary actvity anti-sickle cell anemia of some congolese plants. Epub Nov Oder E, et al. Br J Haematol. Epub Sep 8. Show more similar articles See all similar articles. Shibuya S, et al. Villaret J, et al. Pharm Biol. Myrtle berries seeds aqueous extract abrogates chronic alcohol consumption-induced erythrocytes osmotic stability disturbance, haematological and biochemical toxicity.

Jabri MA, et al. Lipids Health Dis. Safety assessment and antioxidant activity of Lantana montevidensis leaves: Contribution to its phytochemical and pharmacological activity. Barros LM, et al. Precipitating factors and targeted therapies in combating the perils of sickle cell disease A special nutritional consideration. Khan SA, et al. Nutr Metab Lond. Show more "Cited by" articles See all "Cited by" articles. Publication types Research Support, Non-U. Gov't Actions. Humans Actions.

Solubility Actions. Substances Anthocyanins Actions. Antisickling Agents Actions. Hemoglobin, Sickle Actions. Plant Extracts Actions. Copy Download.


Identification of Justicia secunda Vahl by IR spectroscopy

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Justicia secunda Vahl

Jump to navigation. Description Herb or scandent shrub 0. Stem erect or ascending, obtusely quadrangular, shallowly sulcate, at least above glabrous or sparingly puberulous. Petiole slender, mm long, channel puberulous with minute curved trichomes; blade ovate to oblong-ovate, x 2. Inflorescence a terminal panicle, initially small but becoming large and much branched with age, x cm without corollas , flowers secund and crowded or distant mm with age, rachis and peduncle moderately puberulous; peduncle mm long; bracts subtending flowers subulate or narrowly triangular, 1.

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