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Abstract Background Angiopoietin-like protein 8 ANGPTL8 , a newly identified hormone, has been recently characterized as a metabolic regulator which can affect energy homeostasis and has interesting potentials as a metabolic disease therapy. Methods The concentration of ANGPTL8 was analyzed in blood samples of well-characterized individuals whose anthro- pometric parameters, biochemical parameters, and thyroid index were measured.
Thus, it is suggested that thyroid function should be taken into consideration when evaluating the results of ANGPTL8. Haoxiang Li and Mengjiao Xu contributed equally to this work.
Haoxiang Li. Mengjiao Xu. Li Zhao. Hong Xia. Yanyan Li. Xiafei Hong. Xia Deng. Jing Yuan. Yi Ding. Chang Guo. Ruirong Pan. Dong Wang zjdongdonghao aliyun. Jifang Wang. Wei Yin. It is a newly identified protein, composed of amino acids, which is predominant-. Over the past few. Hyperthyroidism is a pathological disorder in which excess thyroid hormone is synthesized and secreted by the thyroid gland. Prevalence of hyperthyroidism is 0. Recently, many studies have demon- strated that changes in thyroid function are associated with changes in energy metabolism [ 16 — 18 ].
Previous research has shown that the levels of circulating hepatocyte- and adipocyte-derived metabolic regulators were. Recently, Han.
Materials and methods. A total of subjects were recruited in this study: GD patients were required to discontinue antithyroid drug ATD therapy for more than 2 weeks before the treat- ment.
Pretreatment protocol also included obtainment of informed consent, negative pregnancy test, ultrasound measured thyroid or nodule volume, hormonal status, and. All patients were placed on a low- dose iodine diet 10 days prior to therapy. Individuals with diabetes mellitus, renal disease, nephritic range protein- uria, coronary heart disease, heart failure, peripheral artery disease, cerebrovascular event and malignancy, or other known major diseases were precluded from the study.
Diagnostic criteria. Anthropometric and biochemical measurements. Height and weight of all patients were measured to the nearest 0. Blood samples were withdrawn from an antecubital vein after a h overnight fasting. After clotting, blood spec- imens were separated by centrifugation.
Serum glucose levels were determined using the glucose oxidase met hod. Thyroidal 1 3 1 I up- take was calculated according to the following equation:. A calibration curve was constructed by plotting. Age year a. SBP mmHg a. DBP mmHg a. Pulse pressure mmHg a. Statistical analysis. All statistical analyses were performed using SPSS version Categorical variables were ex- amined by the x 2 test. Partial correlation coefficients were calculated to evaluate the associations between serum ANGPTL8 and clinical and laboratory measurements.
Partial correlation was used to determine the associations after adjusting for the effects of age, sex, and BMI. Binary logistic. Clinical and biochemical characteristics between the two groups. Compared with those in the control group, pulse pressure,. Age a. BMI a.
SBP a. DBP a. Pulse pressure a. FPG a. GGT a. ALT a. AST a. Triglyceride a. HDL-C a. LDL-C a. APOA a. APOB b. TSH b. TgAb b. TPOAb b. Recently, Han et al. Tseng et al. A study performed by Fenzl et al. In a study of subjects aged 14 — 28 years, Fu et al. It has been widely accepted that thyroid hormone has major effects on the metabolism of lipids [ 28 — 30 ].
Elevated levels of thyroid hormone in hyper- thyroidism are associated with increased clearance of lipolysis and cholesterol. The limitations of our study also require comment. Firstly, this study is limited by its cross-sectional design; thus, only associations not causation between serum ANGPTL8 and thyroid function could be addressed.
Secondly, we divided subjects into groups according to thyroid function prior to random selection, which may have caused selection bias. Thirdly, serum ANGPTL8 levels may be affected by possible and variable acute stress experienced by the individual sub- jects. Due to these limitations, more large-scale population- based prospective studies are warranted. Haoxiang Li, Mengjiao Xu, Li Zhao, and Hong Xia participated in the study design, analyzed the data, and wrote, reviewed, and edited the manuscript.
All authors reviewed and edited the manuscript. Guoyue Yuan and Ling Yang are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Compliance with ethical standards. Informed consent was obtained from participants.
Conflict of interest The authors declare that they have no conflict of interest. Int J Cancer — Santulli G Angiopoietin-like proteins: a comprehensive look. Front Endocrinol Zhang R Lipasin, a novel nutritionally-regulated liver- enriched factor that regulates serum triglyceride levels. Biochem Biophys Res Commun — Cell — Diabetes Care — Int J Endocrinol Pediatr Diabetes — Diabetes Res Clin Pract — Sci Rep Gynecol Endocrinol — J Clin Endocrinol Metab J Clin Endocrinol Metab —
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Abstract Background Angiopoietin-like protein 8 ANGPTL8 , a newly identified hormone, has been recently characterized as a metabolic regulator which can affect energy homeostasis and has interesting potentials as a metabolic disease therapy. Methods The concentration of ANGPTL8 was analyzed in blood samples of well-characterized individuals whose anthro- pometric parameters, biochemical parameters, and thyroid index were measured. Thus, it is suggested that thyroid function should be taken into consideration when evaluating the results of ANGPTL8. Haoxiang Li and Mengjiao Xu contributed equally to this work.
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We thank Venugopal Vandavasi for preliminary studies, Dr. Many of these synaptic organizers are now implicated in neuropsychiatric disorders, underscoring their importance regulating functional neuronal circuits 2. Open 1— The Cstn3 tetramer resembles an unopened flower. Solid phase binding assays were carried out at room temperature.